Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 11339662, compound

HRID 1818389Notes

Reaction equation

HRID 1818389 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C@H:22]2[CH2:27][CH2:26][CH2:25][N:24]([C:28](=[O:30])[CH3:29])[CH2:23]2)[CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.C1(N[C@H]2CCCN(C(=O)C)C2)CCCCC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[C:28]([N:24]1[CH2:25][CH2:26][CH2:27][C@H:22]([N:15]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:31])=[O:3])=[CH:8][N:9]=2)[CH2:23]1)(=[O:30])[CH3:29]

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 66872008HCID 66872008, compoundHCID 86611217HCID 86611217, compound

Product 1

HCID 11339662HCID 11339662, compound

Procedure

{2-[3-(1-Acetyl-piperidin-3 (S)-yl)-3-cyclohexyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester prepared as described in general procedures (A) and (B). using 1-(3 (S)-cyclohexylamino-piperidin-1-yl)-ethanone and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-8e1b03e0eccc42f8aea8356f417ab08d
Source dataset
uspto-grants-2009_10
Patent number
US07598391B2

Reaction notes

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