HCID 57453712, compound → HCID 57438342, compound

HRID 1818505Notes

Reaction equation

OC1C(C(F)(F)F)=C(OCC2C=CC(OC3C=CC=C(C4[N:28]=[N:29][NH:30]N=4)C=3)=CC=2)C=CC=1C(=O)C.[C:35]([C:38]1[CH:60]=[CH:59][C:41]([O:42][CH2:43][C:44]2[CH:58]=[CH:57][C:47]([CH2:48][C:49]3[CH:50]=[C:51]([CH:54]=[CH:55][CH:56]=3)[C:52]#[N:53])=[CH:46][CH:45]=2)=[C:40]([C:61]([F:64])([F:63])[F:62])[C:39]=1[OH:65])(=[O:37])[CH3:36]>>[OH:65][C:39]1[C:40]([C:61]([F:63])([F:64])[F:62])=[C:41]([O:42][CH2:43][C:44]2[CH:58]=[CH:57][C:47]([CH2:48][C:49]3[CH:56]=[CH:55][CH:54]=[C:51]([C:52]4[N:28]=[N:29][NH:30][N:53]=4)[CH:50]=3)=[CH:46][CH:45]=2)[CH:59]=[CH:60][C:38]=1[C:35](=[O:37])[CH3:36]

Participants

Reactant 2

HCID 57453712HCID 57453712, compound

HCID 66699590HCID 66699590, compound

Product 1

HCID 57438342HCID 57438342, compound

Procedure

The title compound is prepared essentially as described for 1-(2-hydroxy-4-{4-[3-(2H-tetrazol-5-yl)-phenoxy]-benzyloxy}-3-trifluoromethyl-phenyl)-ethanone employing 3-[4-(4-acetyl-3-hydroxy-2-trifluoromethyl-phenoxymethyl)-benzyl]-benzonitrile (58%). LC-MS (m/e): 467 (M−1); 1H NMR (DMSO-d6) δ 13.79 (1H, s), 8.21 (1H, d), 7.80-8.00 (2H, m), 7.30-7.60 (6H, m), 6.92 (1H, d), 5.35 (2H, s), 4.08 (2H, s), 2.65 (3H, s).

Sources & evidence

ORD record: ord-a3c0ea0b925d41bd9eca6ad579dbeef1
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598423B2

Reaction notes

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