HCID 57884495, compound → HCID 57884473, compound

HRID 1818525Notes

Reaction equation

HRID 1818525 reaction equation
[C:1](C1C=CC(OCC2C=CC(C(C3C=CC=C(C4NN=NN=4)C=3)NC(=O)C)=CC=2)=C(CCC)C=1O)(=[O:3])[CH3:2].[C:38]([C:41]1[CH:65]=[CH:64][C:44]([O:45][CH2:46][C:47]2[CH:52]=[CH:51][C:50]([CH:53]([NH2:63])[C:54]3[CH:55]=[C:56]([CH:60]=[CH:61][CH:62]=3)[C:57]([OH:59])=[O:58])=[CH:49][CH:48]=2)=[C:43]([CH2:66][CH2:67][CH3:68])[C:42]=1[OH:69])(=[O:40])[CH3:39]>>[C:1]([NH:63][CH:53]([C:50]1[CH:49]=[CH:48][C:47]([CH2:46][O:45][C:44]2[CH:64]=[CH:65][C:41]([C:38](=[O:40])[CH3:39])=[C:42]([OH:69])[C:43]=2[CH2:66][CH2:67][CH3:68])=[CH:52][CH:51]=1)[C:54]1[CH:55]=[C:56]([CH:60]=[CH:61][CH:62]=1)[C:57]([OH:59])=[O:58])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 57884495HCID 57884495, compoundHCID 178439652HCID 178439652, compound

Product 1

HCID 57884473HCID 57884473, compound

Procedure

The title compound is prepared in a similar manner to N-{[4-(4-acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-[3-(1H-tetrazol-5-yl)-phenyl]-methyl}-acetamide employing 3-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-amino-methyl}-benzoic acid to give a white solid (48%). 1H NMR (DMSO-d6) δ 13.01 (bs, 1H), 12.86 (s, 1H), 8.89 (d, 1H), 7.80-7.88 (m, 3H), 7.37-7.57 (m, 6H), 6.72 (d, 1H), 6.20 (d, 1H), 5.25 (s, 2H), 2.57-2.62 (m, 5H), 1.95 (s, 3H), 1.46-1.53 (m, 2H), 0.88 (t, 3H). LCMS M+1 476.

Sources & evidence

ORD record
ord-d4ced47651f84db98eb44d2f976f8919
Source dataset
uspto-grants-2009_10
Patent number
US07598423B2

Reaction notes

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