3-[3-(4-Methoxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl ester → 3-(3-Hydroxymethyl-[1,2,4]oxadiazol-5-ylmethyl)-benzoic acid ethyl ester

HRID 1818596Notes

Reaction equation

HRID 1818596 reaction equation
C(OC(=O)C1C=CC(CC2ON=C(CO)N=2)=CC=1)C.[CH2:20]([O:22][C:23](=[O:46])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][C:31]2[O:35][N:34]=[C:33]([CH2:36][O:37]C3C=CC(OC)=CC=3)[N:32]=2)[CH:25]=1)[CH3:21]>>[CH2:20]([O:22][C:23](=[O:46])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][C:31]2[O:35][N:34]=[C:33]([CH2:36][OH:37])[N:32]=2)[CH:25]=1)[CH3:21]

Participants

3

Reactant 2

HCID 666995003-[3-(4-Methoxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl esterHCID 666995924-(3-Hydroxymethyl-[1,2,4]oxadiazol-5-ylmethyl)-benzoic acid ethyl ester

Product 1

HCID 666995893-(3-Hydroxymethyl-[1,2,4]oxadiazol-5-ylmethyl)-benzoic acid ethyl ester

Procedure

The title compound is prepared essentially as described for 4-(3-hydroxymethyl-[1,2,4]oxadiazol-5-ylmethyl)-benzoic acid ethyl ester, employing 3-[3-(4-methoxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl ester (81%). LC-MS (m/e): 263 (M+1).

Sources & evidence

ORD record
ord-dcc956ce83ca49ae9c7b84a737ff1a89
Source dataset
uspto-grants-2009_10
Patent number
US07598423B2

Reaction notes

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