4-[3-(4-Acetyl-2-chloro-3-hydroxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl ester → 3-[3-(4-Acetyl-2-chloro-3-hydroxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl ester
Reaction equation
C(OC(=O)C1C=CC([CH2:11][C:12]2[O:16][N:15]=[C:14]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([C:25](=[O:27])[CH3:26])=[C:21]([OH:28])[C:20]=3[Cl:29])[N:13]=2)=CC=1)C.[CH2:31]([O:33][C:34](=[O:49])[C:35]1[CH:40]=[CH:39][CH:38]=[C:37](CC2ON=C(CO)N=2)[CH:36]=1)[CH3:32]>>[CH2:31]([O:33][C:34](=[O:49])[C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([CH2:11][C:12]2[O:16][N:15]=[C:14]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([C:25](=[O:27])[CH3:26])=[C:21]([OH:28])[C:20]=3[Cl:29])[N:13]=2)[CH:36]=1)[CH3:32]Participants
3
Reactant 2
Product 1
Procedure
The title compound is prepared essentially as described for 4-[3-(4-acetyl-2-chloro-3-hydroxy-phenoxymethyl)-[1,2,4]oxadiazol-5-ylmethyl]-benzoic acid ethyl ester, employing 3-(3-Hydroxymethyl-[1,2,4]oxadiazol-5-ylmethyl)-benzoic acid ethyl ester (71%). LC-MS (m/e): 429 (M−1).
Sources & evidence
- ORD record
- ord-c00f6e21247b4c0fa12efd8ae5b66d56
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07598423B2
Reaction notes
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