HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 11532876, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Reactant | 2',3'-Dideoxy-3'-fluorouridine | HCID 162450 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11532876 | HCID 11532876 | — |
Reaction Steps
The title compound was synthesised following a similar procedure as described for Example 12. 3′-Fluoro-2′,3′-dideoxyuridine (0.176 g, 0.77 mmol) was reacted with tert-butyldiphenylsilyl chloride (0.238 g, 0.87 mmol) and imidazole (0.116 g, 1.70 mmol) in dry DMF (4 mL) for 3 h. Compound WSP948 was obtained as a white solid (0.331 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601702B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-393c512424434781b5b454507aff1c69 |
| Source note | uspto-grants-2009_10 |