Acetyl chloride → HCID 66841190, compound

HRID 1818674Notes

Reaction equation

HRID 1818674 reaction equation
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([Cl:24])(=O)C>S(Cl)(Cl)=O>[ClH:24].[Cl:24][C:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 223294diphenyl(pyridin-2-yl)methanol

Product 1

HCID 66841190HCID 66841190, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of diphenyl(pyridin-2-yl)methanol (4 g, 0.015 mol) in thionylchloride (50 mL) was added acetylchloride (15 mL, 0.195 mol) at RT and heated to 50° C. for 48 h. The reaction mixture was concentrated under vacuum and the residue was azeotroped with dry benzene (100 mL×2) to give the title compound as the hydrochloride salt (4.4 g, >95%).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customthe residue was azeotroped with dry benzene (100 mL×2)

Sources & evidence

ORD record
ord-a366b01904e1405dbcb963cf6a78306f
Source dataset
uspto-grants-2009_10
Patent number
US07601702B2

Reaction notes

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