Acetic Anhydride → Ethyl (acetyloxy)(4-chloro-3-nitrophenyl)acetate

HRID 1818690Notes

Reaction equation

HRID 1818690 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].[C:18](OC(=O)C)(=[O:20])[CH3:19]>N1C=CC=CC=1>[C:18]([O:14][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N+:15]([O-:17])=[O:16])[CH:4]=1)[C:9]([O:11][CH2:12][CH3:13])=[O:10])(=[O:20])[CH3:19]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 86609828Ethyl (4-chloro-3-nitrophenyl)(hydroxy)acetate

Product 1

HCID 86609827Ethyl (acetyloxy)(4-chloro-3-nitrophenyl)acetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution (6 mL) of the compound (1.46 g) prepared in Example 22 in pyridine, acetic anhydride (2 mL) was added, and the mixture was stirred for 1 hour at room temperature. The title compound (135 mg) having the following physical data was obtained by concentrating the reaction mixture and azeotroping in toluene.

Sources & evidence

ORD record
ord-9e2365e5b0af43d5862d6e13decfd23a
Source dataset
uspto-grants-2009_10
Patent number
US07601712B2

Reaction notes

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