HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane → 1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane | HCID 8078 | — |
| Reactant | HCID 178500931 | HCID 178500931 | — |
| Solvent | 1,4-Dichlorobenzene | HCID 4685 | — |
| Product | 1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester | HCID 57886198 | 65.2% |
Reaction Steps
The hydrazone (28) (500 mg) was dissolved in dichlorobenzene and heated to reflux in a sealed tube for 4 hours. The reaction was allowed to cool and cyclohexane was added dropwise to crystallize the desired product. Filtration and drying in vacuo yielded the desired dihydropyridazine ester (29) (295 mg) as a solid. MS+: m/e=307.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601718B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-76b1633605fd47dd85330c48c70f5914 |
| Source note | uspto-grants-2009_10 |