反应详情

The pyridazine (29) (295 mg) was dissolved in 3 ml of 7N NH3 in methanol and heated to reflux in a sealed tube for 4 hours. The reaction was allowed to cool, neutralized with acetic acid, and concentrated to dryness to give 266 mg of desired amide (30) as a solid. MS+: m/e=292.0 (M+H).

1. temperatureheated
2. temperatureto reflux in a sealed tube for 4 hours
3. temperatureto cool
4. concentrationconcentrated to dryness