Dimethylformamide → HCID 11635391, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[2-(2-methylbenzothiazol-5-yloxy)-1-(piperazinylmethyl)ethyl]-acetamide (18.4 mg) in N,N-dimethylformamide (2 ml) was added ethyldiisopropylamine (500 μl) and chloro-N-(3-phenylphenyl)amide (15.6 mg). The mixture was heated at 75° C. overnight, then solvent removed under reduced pressure, and the residue dissolved in a mixture of methanol/methylene chloride and applied to a preparative TLC plate. The plate was eluted with 4% methanol/methylene chloride and the appropriate fraction collected, providing 2-{4-[2-(acetylamino)-3-(2-methylbenzothiazol-5-yloxy)propyl]piperazinyl}-N-(3-phenylphenyl)acetamide (10 mg).

Provenance & Evidence