1-(Methoxymethyl)cyclopropane-1-sulfonamide → N-Propyl-1-sulfamoylcyclopropane-1-carboxamide

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Reaction Steps

This compound was obtained in an optimized 50% yield from 1-propylcarbamoylcyclopropanesulfonamide tert-butylcarbamate (from Step B.3.a) according to the procedure described for the synthesis of 1-methoxymethylcyclopropylsulfonamide (Step B.1.b), except that no chromatography was used as the material was recrystallized from the minimum amount of CH2Cl2/hexanes: 1H NMR (CDCl3) δ 0.15 (m, 2H), 0.51 (m, 2H), 1.01 (m, 2H), 1.34 (m, 3H), 1.86 (d, J=7.0 Hz, 2H), 4.83 (s, 2H); 13C NMR (CDCl3) δ 4.65, 7.74, 11.26, 35.62, 41.21; LRMS m/z 193 (M++NH4).

Provenance & Evidence