Trifluoroacetic acid → Phthalimidine

Participants

Reaction Steps

A solution of phthalimide (1.0 g, 6.8 mmol) and TFA (5 mL) in ethyl acetate (100 mL) was added 10% Pd—C (1 g). The reaction mixture was hydrogenated at 55 psi for 2 days. Catalyst was then filtered through diatomaceous earth (Celite®) and the filtrate was concentrated to give yellowish solid as crude product (0.37 g). 120 mg of them was then purified by Prep. TLC (eluted with dichloromethane) to give pure 2,3-dihydro-isoindol-1-one (65 mg).

Provenance & Evidence