Phthalimidine → HCID 57885105, compound

Participants

Reaction Steps

To a suspension of NaH (18 mg, 60% dispension in mineral oil, 0.454 mmol) in THF (10 mL), 2,3-dihydro-isoindol-1-one (55 mg, 0.413 mmol) was added. The reaction mixture was stirred at room temperature for 1 hours. The p-nitrophenyl chloroformate (91.5 mg, 0.454 mmol) was added and the reaction mixture was stirred at room temperature for overnight. Solvent was concentrated and the residue was washed with methanol. White solid was collected as pure product carbonic acid 3H-isoindol-1-yl ester 4-nitro-phenyl ester (37 mg, 30% yield).

Provenance & Evidence