Hydrochloric Acid → 3-Benzyl-5-methyl-7-piperazin-1-yl-benzofuran-2-carboxylic acid methylamide

Participants

Reaction Steps

4-(3-Benzyl-5-methyl-2-methylcarbamoyl-benzofuran-7-yl)-piperazine-1-carboxylic acid methyl ester and 4-(3-Benzyl-2-dimethylcarbamoyl-5-methyl-benzofuran-7-yl)-piperazine-1-carboxylic acid isopropyl ester were each separately treated with ethanolic HCl, following the procedure of step 4 of Example 2, to provide 3-benzyl-5-methyl-7-piperazin-1-yl-benzofuran-2-carboxylic acid methylamide ((M+H)+ 364) and 3-benzyl-5-methyl-7-piperazin-1-yl-benzofuran-2-carboxylic acid dimethylamide ((M+H)+ 378) respectively.

Provenance & Evidence