Cesium carbonate → HCID 68709741, compound

HRID 1818804Notes

Reaction equation

HRID 1818804 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[NH:10][S:9]1(=[O:18])=[O:17].C(=O)([O-])[O-].[Cs+].[Cs+].[Br:25][CH2:26]/[CH:27]=[CH:28]/[CH2:29]Br>>[Br:25][CH2:26]/[CH:27]=[CH:28]/[CH2:29][N:10]1[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[S:9]1(=[O:18])=[O:17]

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 641245trans-1,4-Dibromo-2-buteneHCID 468330941-(2-Fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Product 1

HCID 68709741HCID 68709741, compound

Procedure

In an analogous manner to general procedure IV, 1-(2-fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (prepared in an analogous manner as described in general procedure I, 0.264 g, 1.0 mmol) was treated with cesium carbonate (0.49 g, 1.5 mmol) and (E)-1,4-dibromobut-2-ene (1.07 g, 5.0 mmol) to give 0.26 g of 1-[(2E)-4-bromobut-2-en-1-yl]-3-(2-fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide.

Sources & evidence

ORD record
ord-46ad534e126b4262a461d577e567a77e
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

Loading…