rel-(2R,6S)-2,6-dimethylpiperazine → HCID 57886360, compound

HRID 1818815Notes

Reaction equation

HRID 1818815 reaction equation
Br[CH2:2][CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[CH3:20])[S:5]1(=[O:22])=[O:21].[CH3:23][C@H:24]1[CH2:29][NH:28][CH2:27][C@@H:26]([CH3:30])[NH:25]1>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]([CH2:3][CH2:2][N:28]3[CH2:27][C@H:26]([CH3:30])[NH:25][C@H:24]([CH3:23])[CH2:29]3)[S:5]2(=[O:22])=[O:21])=[C:14]([CH3:20])[CH:15]=1

Participants

3

Reactant 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 68711353HCID 68711353, compound

Product 1

HCID 57886360HCID 57886360, compound

Procedure

1-(4-chloro-2-methylphenyl)-3-{2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide was prepared using 1-(2-bromoethyl)-3-(4-chloro-2-methylphenyl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide and cis-2,6-dimethyl piperazine analogous to the conditions used general procedure V.

Sources & evidence

ORD record
ord-ffdf3a5385ad4352b29661025efddf64
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

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