Methylamine ethanol → HCID 68711853, compound

HRID 1818829Notes

Reaction equation

HRID 1818829 reaction equation
[Cl:1][CH2:2]/[CH:3]=[CH:4]\[CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=2[F:22])[S:7]1(=[O:24])=[O:23].[CH3:25][NH2:26].C(O)C>>[ClH:1].[F:22][C:16]1[CH:17]=[C:18]([CH3:21])[CH:19]=[CH:20][C:15]=1[N:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:6]([CH2:5]/[CH:4]=[CH:3]\[CH2:2][NH:26][CH3:25])[S:7]1(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 22028356Methylamine ethanolHCID 68712104HCID 68712104, compound

Product 1

HCID 68711853HCID 68711853, compound

Procedure

A solution of 1-[(2Z)-4-chlorobut-2-en-1-yl]-3-(2-fluoro-4-methylphenyl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide (0.1 g) was stirred in an 8 M methylamine-ethanol solution at 22° C. for 16 h. The reaction mixture was concentrated under reduced pressure to provide (2Z)-4-[3-(2-fluoro-4-methylphenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-N-methylbut-2-en-1-amine hydrochloride (0.12 g) as a white solid:

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-10eef069731b4948895351b6282f3173
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

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