Methylamine → HCID 57886279, compound

Participants

Reaction Steps

In an analogous manner to general procedure V, 1-[2-(2-bromoethoxy)ethyl]-3-(2,4-difluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (0.66 g, 1.5 mmol) was treated with 8N methylamine in methanol to give 2-{2-[3-(2,4-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]ethoxy}-N-methylethanamine which was treated with 1N hydrochloric acid in ether to afford its hydrochloride salt as a white solid (0.10 g, 16%). MS (ES) m/z 384.3 ([M+H]+).

Provenance & Evidence