Dimethylamine → HCID 57886263, compound

HRID 1818852Notes

Reaction equation

HRID 1818852 reaction equation
Br[CH2:2]/[CH:3]=[CH:4]/[CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])[S:7]1(=[O:24])=[O:23].[CH3:25][NH:26][CH3:27]>C(O)C>[F:22][C:16]1[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=1[N:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:6]([CH2:5]/[CH:4]=[CH:3]/[CH2:2][N:26]([CH3:27])[CH3:25])[S:7]1(=[O:24])=[O:23]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 68715158HCID 68715158, compound

Product 1

HCID 57886263HCID 57886263, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In an analogous manner to general procedure V, 1-[(2E)-4-bromobut-2-en-1-yl]-3-(2,4-difluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (0.18 g, 0.43 mmol) was treated with 33% dimethylamine in ethanol to give (2E)-4-[3-(2,4-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-N,N-dimethylbut-2-en-1-amine which was treated with 1N hydrochloric acid in ether to give its hydrochloride salt as a white solid (0.018 g, 10%). MS (ES) m/z 379.8 ([M+H]+).

Sources & evidence

ORD record
ord-8521784d532746d1aaee96618d491d4d
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

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