Methyl iodide → HCID 11391184, compound

Participants

Reaction Steps

8-hydroxy-6-phenyl-3,4-dihydro-pyrano[3,4-c]pyridine-1-on HCl salt (300 mg, 1.080 mmol), iodo methane (3.68 g, 25.92 mmol), silver oxide (936 mg, 4.04 mmol) and calcium sulfate (239.7 mg, 1.76 mmol) were dissolved in 20 mL of anhydrous and then stirred overnight at room temperature. The mixture was evaporated under reduced pressure. A silica gel column chromatography (30% EtOAc/Hexane) was performed on the resulting residue and 193 mg (70%) of 8-methoxy-6-phenyl-3,4-dihydro-pyrano[3,4-c]pyridine-1-on was obtained in white solid.

Provenance & Evidence