Morpholine → HCID 11449741, compound

HRID 1818904Notes

Reaction equation

Cl[C:2]1[N:3]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[C:6]2[CH2:11][CH2:10][O:9][C:8](=[O:12])[C:7]=12.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[N:3]=[C:4]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:5]=[C:6]3[CH2:11][CH2:10][O:9][C:8](=[O:12])[C:7]=23)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 11414273HCID 11414273, compound

Product 1

HCID 11449741HCID 11449741, compound

Procedure

128 mg (98%) of 8-morpholine-4-yl-6-phneyl-3,4-dihydro-pyrano[3,4-c]pyridine-1-on was obtained in white solid using the method same as in Example 35 except that 110 mg of 8-chloro-6-phenyl-3,4-dihydro-pyrano[3,4-c]pyridine-1-on was added with morpholine instead of 4-fluoro-aniline.

Sources & evidence

ORD record: ord-d9128bcf29ea46559ddc0624bb618993
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07601736B2

Reaction notes

Loading…