Lawesson's reagent → 3,4-Dihydro-pyrano[3,4-c]pyridine-1-thione

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Reaction Steps

3,4-dihydro-pyrano[3,4-c]pyridine-1-on (250 mg, 1.676 mmol) was dissolved in anhydrous toluene and stirred overnight at room temperature after adding Lawesson reagent (420 mg, 1.005 mmol). The mixture was evaporated under reduced pressure and a silica gel column chromatography (70% EtOAc/Hexane) was performed on the resulting residue and obtained 200 mg (72%) of 3,4-dihydro-pyrano[3,4-c]pyridine-1-thione in yellow solid.

Provenance & Evidence