HCID 11948308, compound → HCID 11368408, compound

HRID 1818915Notes

Reaction equation

HRID 1818915 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[C:6]2[C:11]=1[C:10](=[O:12])[NH:9][CH:8]=[CH:7]2.[H][H]>[Pd].C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[C:6]2[C:11]=1[C:10](=[O:12])[NH:9][CH2:8][CH2:7]2

Participants

5

Reactant 2

HCID 11948308HCID 11948308, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11368408HCID 11368408, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

8-methyl-6-phenyl-2H-[2,7]naphtyridine-1-on (500 mg, 2.116 mmol) was suspended in anhydrou ethanol, added with 5% Pd/C (400 mg) and then stirred at room temperature under the hydrogen atmosphere for about 72 hours. The mixture was filtered and then concentrated under reduced pressure. A silica gel column chromatography (2% MeOH/MC) was performed on the resulting residue and obtained 462 mg (92%) of 8-methyl-6-phenyl-3,4-dihydro-2H-[2,7]naphtyridine-1-on in white solid.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3e9e72e83955449e90a7890922d0353e
Source dataset
uspto-grants-2009_10
Patent number
US07601736B2

Reaction notes

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