HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenyl isocyanate → (2-{4-[3-(3-Trifluoromethyl-phenyl)-ureido]-imidazol-1-yl}ethyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| Reactant | Tert-butyl 2-(4-amino-1H-imidazol-1-YL)ethylcarbamate | HCID 68425567 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-{4-[3-(3-Trifluoromethyl-phenyl)-ureido]-imidazol-1-yl}ethyl)-carbamic acid tert-butyl ester | HCID 68422862 | 75% |
Reaction Steps
To a solution of compound 39.3 in dichloromethane under nitrogen was added 3-trifluoromethylphenyl isocyanate dropwise. After about 0.1 hour, a white precipitate formed. The precipitate was filtered off, washed with dichloromethane and dried under high-vacuum to yield 485 mg (75%) of (2-{4-[3-(3-trifluoromethyl-phenyl)-ureido]-imidazol-1-yl}ethyl)-carbamic acid tert-butyl ester (compound 39.4) as a white solid, ES (+) MS m/e=414 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601725B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-328b9da48c0f4f2790743585c9a0f2fc |
| Source note | uspto-grants-2009_10 |