Aluminium lithium hydride → HCID 86603190, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound 74.1 (0.08 mmol) in THF (1.0 mL) is added LAH (0.24 mL of 1.0 M solution in THF) and the reaction mixture is heated at 50° C. for 4 hours. The reaction is quenched with the dropwise addition of saturated NH4Cl, the volatiles are removed under reduced pressure and then extracted with EtOAc. The combined organic layers are filtered and concentrated to provide 1-[5-(2-amino-1-hydroxymethyl-ethyl)-thiazol-2-yl]-3-(3-trifluoromethyl-phenyl)-urea (compound 74.2) of sufficient purity for use in the next step.

Provenance & Evidence