Methyl iodide → HCID 178503995, compound

Participants

Reaction Steps

A solution of compound 79.2 (1.5 mmol) and methyl iodide (6.0 mmol) in acetone (15.0 mL) was stirred at 40° C. overnight. The solvent was removed and the residue was dried in vacuo to give {2-[4-(2-methyl-isothioureido)-phenyl]-ethyl}-carbamic acid tert-butyl ester (compound 79.3) in quantitative yield. 1H NMR (CD3OD, 400 MHz): δ 7.40 (d, J=7.8 Hz, 2H), 7.28 (d, J=8.3 Hz, 2H), 3.30 (t, J=7.1 Hz, 2H), 2.82 (t, J=7.1 Hz, 2H), 2.73 (s, 3H) ppm; EIMS (m/z): 310.1 (M++H).

Provenance & Evidence