3-Fluoro-2-(trifluoromethyl)benzyl bromide → HCID 57886055, compound

HRID 1819081Notes

Reaction equation

HRID 1819081 reaction equation
[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][C:8](=[O:10])[NH:9][C:4]=2[CH:3]=1.[F:13][C:14]1[C:15]([C:22]([F:25])([F:24])[F:23])=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17]Br>>[F:13][C:14]1[C:15]([C:22]([F:23])([F:24])[F:25])=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17][N:9]1[C:8](=[O:10])[CH2:7][NH:6][C:5]2[N:11]=[CH:12][C:2]([I:1])=[CH:3][C:4]1=2

Participants

3

Reactant 2

HCID 27747933-Fluoro-2-(trifluoromethyl)benzyl bromideHCID 448291147-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one

Product 1

HCID 57886055HCID 57886055, compoundYield 54%

Procedure

7-Iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (1.051 g) was alkylated with 3-fluoro-2-(trifluoromethyl)benzyl bromide as in General Procedure 1 to give the title compound as a light brown solid (54% yield). M.p.>200° C., LCMS: m/z=451.79 (M+H+), 1H-NMR (DMSO-d6, 400 MHz) δ 4.17 (2H, s), 5.20 (2H, bs), 7.01 (1H, d, J=7.6 Hz), 7.17 (1H, s), 7.23 (1H, s), 7.42 (1H, m), 7.63 (1H, m), 7.86 (1H, m).

Sources & evidence

ORD record
ord-c0afd15155a84582a0d72abee47b1490
Source dataset
uspto-grants-2009_10
Patent number
US07601716B2

Reaction notes

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