2-(Trifluoromethoxy)benzyl bromide → HCID 57886035, compound

HRID 1819130Notes

Reaction equation

HRID 1819130 reaction equation
[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][C:8](=[O:10])[NH:9][C:4]=2[CH:3]=1.[F:13][C:14]([F:25])([F:24])[O:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18]Br>>[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][C:8](=[O:10])[N:9]([CH2:18][C:17]3[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=3[O:15][C:14]([F:13])([F:24])[F:25])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 27772542-(Trifluoromethoxy)benzyl bromideHCID 448291147-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one

Product 1

HCID 57886035HCID 57886035, compoundYield 61%

Procedure

7-Iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (942 mg) was reacted with 2-(trifluoromethoxy)benzyl bromide as in General Procedure 1 to give the title compound as a light yellow solid (61% yield). m.p.=235° C., LCMS: m/z=449.92 (M+H+), 1H-NMR (CDCl3, 400 MHz) δ 4.29 (2H, s), 4.89 (1H, s), 5.16 (2H, s), 7.09 (2H, m), 7.24 (1H, m), 7.34 (2H, m), 7.92 (1H, s).

Sources & evidence

ORD record
ord-aaa170a310cf40eb8e6582bc111b67f9
Source dataset
uspto-grants-2009_10
Patent number
US07601716B2

Reaction notes

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