HRID1819155

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2794808

4-(Piperazin-1-yl)furo[3,2-c]pyridine

C11H13N3O

结构：O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1

HCID58327807

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1)N1CCN(c2nccc3occc23)CC1

HCID58327801

未命名化合物

PROCEDURE

实验过程

3-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 1-(4-furo[3,2-c]pyridinyl)piperazine as in General Procedure 10 to give the title compound. LCMS: m/z=633.99 (M+H+); retention time=0.64 minutes.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3564ecbfb9e44abb1a18cb1442830b6
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07601716B2
来源说明: uspto-grants-2009_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=3)[C:21]([OH:23])=O)=[CH:17][C:9]1=2.[O:32]1[C:40]2[CH:39]=[CH:38][N:37]=[C:36]([N:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)[C:35]=2[CH:34]=[CH:33]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:30])([F:31])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([C:21]([N:44]4[CH2:45][CH2:46][N:41]([C:36]5[C:35]6[CH:34]=[CH:33][O:32][C:40]=6[CH:39]=[CH:38][N:37]=5)[CH2:42][CH2:43]4)=[O:23])[CH:24]=[CH:25][CH:26]=3)=[CH:17][C:9]1=2