1,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one → HCID 58327786, compound

HRID 1819203Notes

Reaction equation

HRID 1819203 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=3)=[CH:17][C:9]1=2.[NH:32]1[CH2:37][CH2:36][CH:35]([N:38]2[C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=3[NH:40][C:39]2=[O:47])[CH2:34][CH2:33]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:29])[F:30])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[CH:20][C:21]([C:22]([N:32]4[CH2:33][CH2:34][CH:35]([N:38]5[C:42]6[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=6[NH:40][C:39]5=[O:47])[CH2:36][CH2:37]4)=[O:23])=[CH:25][CH:26]=3)=[CH:17][C:9]1=2

Participants

3

Reactant 2

HCID 886381,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-oneHCID 469067184-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid

Product 1

HCID 58327786HCID 58327786, compound

Procedure

4-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 1,3-dihydro-1-(4-piperidinyl)benzoimidazol-2-one as in General Procedure 10 to give the title compound. LCMS: m/z=647.03 (M+H+); retention time=0.81 minutes.

Sources & evidence

ORD record
ord-7416733922b249ca93254b44503eae4f
Source dataset
uspto-grants-2009_10
Patent number
US07601716B2

Reaction notes

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