Acetic Acid → HCID 57567032, compound

Participants

Reaction Steps

A mixture of 1-(3-aminophenyl)-4-(3-cyclopentyloxy-4-methoxyphenyl)-pyrrolidin-2-one (8 mg, 0.02 mmol), (tetrahydrofuran-3-yl)-acetaldehyde (0.024 mmol), NaB(OAc)3H (0.2 mmol), and AcOH (0.06 mmol) in DMF (0.5 mL) was stirred for 20 h. After concentration under reduced pressure, the residue was dissolved in EtOAc (3 mL), washed with brine (2×3 mL), and dried over Na2SO4. Concentration and chromatography on silica gel (EtOAc:Hexane=1:1) gave 5.2 mg of the desired product. Yield: 57%.

Provenance & Evidence