Trifluoroacetic acid methylene chloride → HCID 68828101, compound

HRID 1819343Notes

Reaction equation

HRID 1819343 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[CH3:28])[CH:14]=2)[CH2:10][C:9]1=[O:29])=O)(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([CH:11]2[CH2:12][NH:8][C:9](=[O:29])[CH2:10]2)=[CH:14][C:15]=1[O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH3:28]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 68831139HCID 68831139, compound

Product 1

HCID 68828101HCID 68828101, compound

Procedure

The deprotection of 4-(4-methoxy-3-o-tolyloxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester was performed in a 25% TFA/DCM solution. This solution was stirred for 30 min at r.t. After neutralization and extraction in EtOAc, the mixture was concentrated under reduced pressure to give the desired compound without purification.

Workup

  1. extractionAfter neutralization and extraction in EtOAc
  2. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-256edb9e90ba45e8b7473eac5fe30859
Source dataset
uspto-grants-2009_10
Patent number
US07601742B2

Reaction notes

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