4-Benzyl-3-[3-(4-benzyloxy-3-cyclopentyloxyphenyl)-4-nitrobutyryl]-oxazolidin-2-one → 4-(4-Benzyloxy-3-cyclopentyloxyphenyl)pyrrolidin-2-one

Participants

Reaction Conditions

Reaction Steps

Nitro-compound 16 (4 g) was partially dissolved in 75 mL EtOAc/75 mL EtOH/75 mL dioxane, and a suspension of Raney Ni was added. The mixture was flushed with H2 three times. The mixture was stirred under H2 at 50° C. overnight, then filtered through celite. Concentration and chromatography of the residue on silica gel gave 2.2 g of the desired product. Yield: 88%.

Provenance & Evidence