HCID 57566928, compound → HCID 57567009, compound

HRID 1819367Notes

Reaction equation

HRID 1819367 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:17]2[CH2:21][N:20]([C:22]3[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=3)[C:25]([NH2:27])=[O:26])[C:19](=[O:31])[CH2:18]2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH:17]2[CH2:21][N:20]([C:22]3[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=3)[C:25]([NH2:27])=[O:26])[C:19](=[O:31])[CH2:18]2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

4

Reactant 1

HCID 57566928HCID 57566928, compound

Product 1

HCID 57567009HCID 57567009, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 29 (0.9 g, 2.26 mmol) in EtOH (15 mL) was added 10% Pd/C. The solution was then placed under vacuum and recharged with H2. The reaction mixture was stirred under H2 overnight. After filtration and removal of solvent, the residue was placed under vacuum for 10 h to give 30. Etherification of 30 was performed as set forth in Example 27.

Workup

  1. filtrationAfter filtration and removal of solvent
  2. waitthe residue was placed under vacuum for 10 h

Sources & evidence

ORD record
ord-0bbc490953424492935200fdee3cdb74
Source dataset
uspto-grants-2009_10
Patent number
US07601742B2

Reaction notes

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