tert-Butoxycarbonyl-L-isoleucine → HCID 178446792, Verbindung

HRID 1819373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1819373
[C:1]([O:5][C:6]([N:8]1[CH:17]([CH:18]([OH:22])[CH:19]([OH:21])[CH3:20])[CH2:16][NH:15][C:14]2[NH:13][C:12]([N:23]=[CH:24][N:25]([CH3:27])[CH3:26])=[N:11][C:10](=[O:28])[C:9]1=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:29]([NH:36][C@H:37]([C:42](O)=[O:43])[C@H:38]([CH2:40][CH3:41])[CH3:39])([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>>[C:1]([O:5][C:6]([N:8]1[CH:17]([CH:18]([OH:22])[CH:19]([O:21][C:42](=[O:43])[CH:37]([NH:36][C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])[CH:38]([CH3:39])[CH2:40][CH3:41])[CH3:20])[CH2:16][NH:15][C:14]2[NH:13][C:12]([N:23]=[CH:24][N:25]([CH3:26])[CH3:27])=[N:11][C:10](=[O:28])[C:9]1=2)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 2724762tert-Butoxycarbonyl-L-isoleucineHCID 178469704HCID 178469704, Verbindung

Produkt 1

HCID 178446792HCID 178446792, VerbindungAusbeute 48 %

Versuchsvorschrift

The product of Example 5, step b) was treated by the same method as that described in Example 5, step c) except N-Boc-L-Isoleucine (3.70 g, 16 mmol) was used to give the sub-title compound as a light yellow solid (0.29 g, 48%). The product obtained after chromatography still contained impurities and was used for the next step without further purification. MS: ESI (positive): 610 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-726adc5728f74f5084c315771572aec4
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07601717B2

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