1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → Pyrrolidine-1,2-dicarboxylic acid 2-{2-[5-tert-butoxycarbonyl-2-(dimethylamino-methyleneamino)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-yl]-2-hydroxy-1-methyl-ethyl}ester 1-tert-butyl ester

Participants

Reaction Steps

The product of Example 5, step b) was treated by the same method as that described in Example 5, step c) except N-Boc-L-Proline (13.6 g, 63.1 mmol) was used to give the sub-title compound as a tan solid (5.2 g, 69%). MS: ESI (positive): 594 (M+H).

Provenance & Evidence