Potassium thiocyanate → 2-Chloro-5-nitropyrimidin-4-yl thiocyanate

Participants

Reaction Conditions

Reaction Steps

2,4-Dichloro-5-nitropyrimidine (12 g) was dissolved in AcOH (70 mL) and cooled to 0° C. Potassium thiocyanate (6.31 g) was added portion-wise to the solution over 2 h. The reaction was diluted with water and filtered. The filter cake was washed with cold ether to afford the desired 2-chloro-5-nitro-4-thiocyanatopyrimidine (9.5 g, 71%).

Provenance & Evidence