反应详情

To a solution of the above (5-nitro-4-thiocyanato-pyrimidin-2-yl)-phenethyl-amine (75 mg, 0.25 mmol) in CH2Cl2 was added tert-butyl trans-4-aminomethylcyclohexylcarbamate (114 mg, 0.5 mmol). The reaction mixture was stirred at room temperature for 16 h and concentrated in vacuo. The resulting residue was then diluted with CH2Cl2 (1 mL) and TFA (0.5 mL) was added. The mixture was stirred at room temperature for 4 h and concentrated in vacuo. The resulting residue was purified by preparative LCMS to afford 36 mg (39%) of the title compound, m/z 371.6 [M+1]+.

1. concentrationconcentrated in vacuo
2. additionThe resulting residue was then diluted with CH2Cl2 (1 mL) and TFA (0.5 mL)
3. additionwas added
4. stirringThe mixture was stirred at room temperature for 4 h
5. concentrationconcentrated in vacuo
6. customThe resulting residue was purified by preparative LCMS