1,3-Dibromopropane → HCID 178510353, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-{[(trans-4-aminocyclohexyl)methyl]amino}-2-{[2-(trifluoromethoxy)benzyl]-amino}pyrimidine-5-carbonitrile (150 mg, 0.36 mmol) in DMF (1 mL) were added 1,3-dibromo-propane (86 mg, 0.43 mmol) and DIPEA (124 μL, 0.71 mmol). The reaction mixture was stirred at 50° C. for 24 h. The reaction mixture was then diluted with EtOAc and washed with NaHCO3 (×1) and water (×4). The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo. The resulting residue was purified by silica gel preparative TLC using 10:1:0.2 CH2Cl2:MeOH:NH4OH as an eluent to afford 54 mg (33%) of the title compound as a white solid, m/z 461.6 (M+1)+.

Provenance & Evidence