2-Bromoacetamide → HCID 178510355, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromoacetamide (30 mg, 0.21 mmol), 4-{[(trans-4-aminocyclohexyl)methyl]amino}-2-{[2-(trifluoromethoxy)benzyl]amino}pyrimidine-5-carbonitrile (117 mg, 0.28 mmol) and DIPEA (74 mL, 0.43 mmol) in DMF (1 mL) was stirred at 50° C. for 4 h. The reaction mixture was then diluted with EtOAc (30 mL) and washed with water (3×3 mL) and brine. The organic phase was dried over Na2SO4 and concentrated. Silica gel preparative TLC of the crude product using 10:1:0.05 CH2Cl2:MeOH:NH4OH as an eluent afforded 28 mg (27%) of the title compound as a white solid, m/z 476.5 [M−1]+

Provenance & Evidence