Ethyl isocyanate → HCID 178465353, compound

Participants

Reaction Steps

To a solution of N4-[(trans-4-aminocyclohexyl)methyl]-5-nitro-N2-[2-(trifluoromethoxy)benzyl]-pyrimidine-2,4-diamine (100 mg, 0.23 mmol) in DMF (2 mL) was added ethyl isocyanate (65 mg, 0.91 mmol). The reaction mixture was stirred at room temperature for 16 h. The resulting precipitate was filtered and triturated in MeOH. The solid was dried in a vacuum oven to afford 47 mg (41%) of the title compound, m/z 512.7 [M +1]+

Provenance & Evidence