Hydrochloric Acid → HCID 178511547, compound

Participants

Reaction Steps

[trans-4-({2-[(2-Methoxy-pyridin-3-ylmethyl)-amino]-5-nitro-pyrimidin-4-ylamino}-methyl)-cyclohexyl]-carbamic acid tert-butyl ester (100 mg, 0.205 mmol) was dissolved in dioxane (2 mL) and treated with HCl in dioxane (0.85 mL, 4 mmol/mL, 3.40 mmol). After stirring overnight, an oil was seen at the bottom of the solution. The solvent was taken out and the residue dried to give an oily solid. The crude solid was purified with prep TLC (1:9:90 NH3:MeOH:DCM) to give the title product (20.5 mg, 0.055 mmol, 26.8%) as a yellow solid, m/z 374.5 (M+1)+

Provenance & Evidence