反应详情

To a 2 N solution of NH3 in MeOH (40 mL) in a high pressure autoclave was added cis-4-hydroxy-cyclohexanecarbonitrile (6.6 g, 52.7 mmol) and Raney Ni (1.0 g, 17 mmol, 0.3 equiv.) The mixture was placed under 45 psi H2 and shaken overnight. The pressure was released and the reaction filtered through a pad of Celite. The filter pad was washed with EtOAc and the mixture was concentrated under reduced pressure to provide a yellow oil as cis-4-aminomethyl-cyclohexanol (6.3 5g, 49.1 mmol, 93.2%).

1. filtrationthe reaction filtered through a pad of Celite
2. washThe filter pad was washed with EtOAc
3. concentrationthe mixture was concentrated under reduced pressure