Hydrochloric Acid → HCID 69065387, compound

Participants

Reaction Steps

To a THF (100 mL) solution of triethyl-2-phosphonopropionic acid (33.8 mL) was added sodium hydride (8.4 g) under ice-cooling. After the reaction mixture was stirred for 1 h, to the reaction mixture was added a THF solution of 4-bromo-2,6-difluorobenzaldehyde (2) (23.2 g) dropwise under ice-cooling. After the reaction mixture was stirred under ice-cooling for 2 h, to the reaction mixture were added ice-water, 2N hydrochloric acid, and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water, and brine, dried over magnesium sulfate, and evaporated. The obtained residue was purified by column chromatography (hexane:ethyl acetate=15:1) to obtain the compoumd (3) 32.08 g.

Provenance & Evidence