反应详情

温度

130 °C

2-Isopropylphenol (6 g) was dissolved in acrylic acid tert-butyl ester (6.2 g), and to the mixture was added potassium tert-butyloxide (0.3 g). The reaction mixture was stirred at 130° C. for 6 h. To the reaction mixture was added water, the reaction mixture extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated. The obtained residue was purified by column chromatography (hexane:ethyl acetate=9:1) to obtain the compound (10) 4.3 g.

1. extractionthe reaction mixture extracted with ethyl acetate
2. washThe organic layer was washed with brine
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. customThe obtained residue was purified by column chromatography (hexane:ethyl acetate=9:1)