Water → HCID 57887232, compound

Participants

Reaction Conditions

Reaction Steps

4-[2-Fluoro-3-(1-methyloxyhexyl)phenyl]thiazol-2-ylamine (460 mg) and methyl (Z)-3-(4-bromo-2,6-difluorophenyl)-2-methyloxyacrylate (462 mg), and dichlorobistriphenylphosphinepalladium (150 mg) were dissolved in DMF (6 mL). Triethylamine (0.84 mL) was added into the mixture, and the reaction mixture was stirred under carbon monoxide atomosphere at 85° C. for 16 h. Water added into the reaction mixture, and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water, and brine, dried over magnesium sulfate, evaporated. The obtained residue was purified by Colum chromatography (hexane:ethyl acetate=4:1) to obtain the compound (24) 630 mg.

Provenance & Evidence