Sodium Hydroxide → HCID 131727657, compound

HRID 1819513Notes

Reaction equation

HRID 1819513 reaction equation
[CH2:1]([O:5][CH:6]([C:9]1[C:10]([F:36])=[C:11]([C:15]2[N:16]=[C:17]([C:20]([C:22]3[CH:27]=[C:26]([F:28])[C:25]([CH:29]=[C:30]([CH3:34])[C:31]([OH:33])=[O:32])=[C:24]([F:35])[CH:23]=3)=[O:21])[S:18][CH:19]=2)[CH:12]=[CH:13][CH:14]=1)[CH2:7][CH3:8])[CH2:2][CH2:3][CH3:4].[OH-].[Na+:38]>CO>[Na+:38].[Na+:38].[CH2:1]([O:5][CH:6]([C:9]1[C:10]([F:36])=[C:11]([C:15]2[N:16]=[C:17]([C:20]([C:22]3[CH:23]=[C:24]([F:35])[C:25]([CH:29]=[C:30]([CH3:34])[C:31]([O-:33])=[O:32])=[C:26]([F:28])[CH:27]=3)=[O:21])[S:18][CH:19]=2)[CH:12]=[CH:13][CH:14]=1)[CH2:7][CH3:8])[CH2:2][CH2:3][CH3:4].[CH2:1]([O:5][CH:6]([C:9]1[C:10]([F:36])=[C:11]([C:15]2[N:16]=[C:17]([C:20]([C:22]3[CH:23]=[C:24]([F:35])[C:25]([CH:29]=[C:30]([CH3:34])[C:31]([O-:33])=[O:32])=[C:26]([F:28])[CH:27]=3)=[O:21])[S:18][CH:19]=2)[CH:12]=[CH:13][CH:14]=1)[CH2:7][CH3:8])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69058736HCID 69058736, compound

Product 1

HCID 131727657HCID 131727657, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of methanol (100 mL) solution of 3-(4-{4-[3-(1-n-butyloxypropyl)-2-fluorophenyl]thiazol-2-ylcarbonyl}-2,6-difluorophenyl)-2-methylacrylic acid (3.22 mg) was added 2M sodium hydroxide aqueous solution (6.06 mL). After stirring for 1 h, n-hexylaldehyde (5.88 mL) was added to the reaction mixture. After methanol was evaporated under reduced pressure, the obtained residue was redissolved by adding water (40 mL). The water solution was freeze drying to obtain the compound (C1) 3.40 g.

Workup

  1. customAfter methanol was evaporated under reduced pressure
  2. dissolutionthe obtained residue was redissolved
  3. additionby adding water (40 mL)
  4. customdrying

Sources & evidence

ORD record
ord-36ef6326e1e340c29472c98e9b082568
Source dataset
uspto-grants-2009_10
Patent number
US07601746B2

Reaction notes

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