Piperidine → HCID 69066473, compound

Participants

Reaction Conditions

Reaction Steps

(2S,4S)-4-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (160 mg) was dissolved in CH2Cl2 (2 ml) and piperidine (43 μl) was added. The mixture was stirred for 17 h at 25° C. The crude product was purified by chromatography (silica gel; gradient: CH2Cl2->methanol 2N NH3) to yield (2S,4S)-4-amino-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester as colorless amorphous solid (96 mg). MH+=417.5

Provenance & Evidence