HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-5-(3-oxo-morpholin-4-yl)-benzonitrile → 2-Amino-5-(3-oxo-morpholin-4-YL)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-5-(3-oxo-morpholin-4-yl)-benzonitrile | HCID 58826466 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | 2-Amino-5-(3-oxo-morpholin-4-YL)-benzonitrile | HCID 53416464 | 60% |
Reaction Steps
2-Nitro-5-(3-oxo-morpholin-4-yl)-benzonitrile (1.1 g) was dissolved in THF (80 ml) and hydrogenated with hydrogen (1 atm) over Pd/C 10% (350 mg) for 18 h at 25° C. The reaction mixture was then filtered through decalite and precipitated (AcOEt/heptane) to yield 2-amino-5-(3-oxo-morpholin-4-yl)-benzonitrile as a white solid (580 mg). MH+=218.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601752B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-babec7680ff04e789b9bc3a12ed08238 |
| Source note | uspto-grants-2009_10 |